Heavy smoke from 2nd floor reported by Engine 6. All occupants of the home were accounted for and Engine 6 initiated interior attack on fire. Engine 1 used pre connected attack line on 2nd floor with Engine 3 backing up Engine 6 on 1st floor. Due to weather and fire conditions a 2nd alarm was struck. Ladder companies provided ventilation and second alarm companies assisted with checking for fire extension. Fire was controlled under very adverse conditions.